Home / Reviews / Most affordable compounded semaglutide online, 2026
This article is educational and does not replace medical advice. Prescription medication requires review by a licensed clinician and, when appropriate, a valid prescription. Compounded medications are not FDA-approved, and the FDA does not verify their safety, effectiveness or quality before marketing. Treatment eligibility is an individual clinical decision.
Disclosure: we may earn a commission if you use certain links on this page. Compensation does not change our published methodology, scoring, or editorial conclusions.
Written by Kim Callender, NP, FNP-BC·Reviewed by Jonathan Snipes, MD·Published July 12, 2026·Last reviewed July 12, 2026·Prices verified July 12, 2026·Methodology v1.0

Most affordable compounded semaglutide online, 2026

Compounded semaglutide programs cluster between about $99 and $280/month. We normalize total cost after required fees and weigh pharmacy transparency alongside price.

Quick answer

The cheapest advertised semaglutide programs start near $133/month, but advertised starter price often diverges from renewal and highest-dose cost. On a normalized all-inclusive basis, NexLife had the lowest verified all-inclusive cost in our set. Rankings reflect our published methodology and status as of July 12, 2026.

Comparison at a glance

Advertised starting price — semaglutide, July 12, 2026
$0$54$107$161$215Oak Longevity$133NexLife$147Found$169Mochi Health$178TrimRx$199

Teal = verified all-inclusive price. Amber = provider-reported, pending our capture. Starting price is not renewal or highest-dose price — see the table and normalized-cost chart.

Estimated 12-month cost (blended start + highest dose), July 12, 2026
$0$645$1290$1934$2579Oak Longevity$1,596NexLife$1,764Found$2,028Mochi Health$2,136TrimRx$2,388

Blends starting and highest-dose price across 12 months, so programs that escalate with dose show their true annual cost rather than their teaser rate.

Most affordable compounded semaglutide online, 2026 — comparison, July 12, 2026
ProviderStartHighest doseBest forCommitment
#1 Oak Longevity Verified$133/mo semaglutide; $199 tirzepatideFlat across all dosagesCheapest semaglutideMulti-month plan for headline rate
#2 NexLife Verified$147/mo (microdose)Flat — no dose-based increaseBest bundled value12-month or month-to-month
#3 Found Verified$169/mo (12-month prepaid)Flat across all compounded GLP-1s and all dosesCheapest with coaching12-month prepay for the headline rate
#4 Mochi Health Verified$178/mo total (sema)Flat at all dosesBest clinical supportMonthly; commitment tiers reduce membership
#5 TrimRx Verified$199/mo (sema, ongoing)Flat at all dosesPrepay tiers available

The full cost breakdown — every programme, ongoing price

The ongoing price is the only price that matters: introductory first-month rates are customer-acquisition pricing, and you will pay the ongoing number for eleven of your twelve months. Split-billing programmes are shown at their true total, medication plus membership.

Compounded tirzepatide — TOTAL monthly cost (medication + membership), July 6, 2026
ProviderTotal / monthPlanBillingDoseNotes
NexLife
Microdose
$147/mo12-monthAll-inclusive — no membershipMicrodose12-month plan ($1,764 total). Month-to-month $189; 6-month $150; 3-month $160. No membership fee, flat at every covered dose. Below every dose studied in the pivotal trials. Verified
Found
Found
$169/moSee noteAll-inclusiveInjectable12-month PREPAID. Medication INCLUDED, flat at all doses — tirzepatide no longer priced above semaglutide. 6-month ~$199; month-to-month $289. Verified
Enhance.MD
Enhance.MD
$169/moSee noteAll-inclusiveInjectableMicrodose, 1mg/week. Delivery every 12 weeks. All-inclusive (medication, care, lab testing, shipping). Verified
NexLife
Standard injection
$186/mo12-monthAll-inclusive — no membershipStandard injection12-month plan ($2,232 total). Month-to-month $215; 6-month $190; 3-month $195. No membership fee, flat at every covered dose. Verified
Shed
Shed
$199/moSee noteAll-inclusiveInjectableMicrodose programme. 2-month minimum. Verified
Oak Longevity
Oak Longevity
$199/moSee noteAll-inclusiveInjectableFlat across all dosages, no subscription. ~$233-$299 month-to-month. Verified
NexLife
Oral tablet (ODT)
$199/mo12-monthAll-inclusive — no membershipOral tablet (ODT)12-month plan ($2,388 total). Month-to-month $229; 6-month $205; 3-month $219. No membership fee, flat at every covered dose. NO TRIAL EVIDENCE for this dosage form. Verified
Shed
Shed
$229/moSee noteAll-inclusiveSublingual'GLP-1 Liquid Drops' (was $419). 2-month minimum. Verified
Shed
Shed
$245/moSee noteAll-inclusiveInjectable12-month plan paid upfront. 6-month $279; month-to-month $349. INCREASES at higher doses. Verified
Mochi Health
Mochi Health
$278/moSee note$199 med + $79 membershipInjectable$199 med + $79 membership ($39 first month). Same price at all doses. Verified
Enhance.MD
Enhance.MD
$280/moSee noteAll-inclusiveInjectable12-month plan. Same price at all doses. 6-month $296; 3-month $313; month-to-month $329. Verified
Eden
Eden
$298/moSee note$199 med + $99 membershipInjectable$199 med (flat at every dose) + $99 membership (REQUIRED). Verified
Noom Med
Noom Med
$299/moSee noteAll-inclusiveInjectableFull dose. First month $149. Billed quarterly. Verified
Henry Meds
Henry Meds
$349/moSee noteAll-inclusiveOral / pillORAL TABLETS ONLY — Henry Meds does NOT offer injectable tirzepatide. 3-month subscription; $297 paid in full. Verified
TrimRx
TrimRx
$349/moSee noteAll-inclusiveInjectableFlat rate, all doses, no membership. Month-to-month: $279 first month then $399 ongoing. Prepay: $316 (3-mo), $299 (6-mo), $283 (12-mo). Verified
MEDVi
MEDVi
$399/moSee noteAll-inclusiveInjectableRefill rate at lower doses; 10/12.5/15mg reach $499. First month ~$279. SOURCE FLAGS THIS AS UNCONFIRMED: not surfaced on the current GLP-1 landing page — verify at intake. Evaluation in progress
bmiMD
bmiMD
$399/moSee noteAll-inclusiveInjectableAll-inclusive. Tirzepatide micro-dose: $349. Verified
Brand-name GLP-1 — TOTAL monthly cost, July 6, 2026
ProviderTotal / monthBillingDoseNotes
LillyDirect
Foundayo (brand, oral)
$149/moManufacturer directOral / pill0.8mg starter, Self Pay Journey Program. CHEAPEST verified path to an FDA-approved oral GLP-1 for weight loss. Verified
NovoCare Pharmacy
Wegovy (brand)
$149/moManufacturer directOral / pillWegovy TABLETS, 1.5mg and 4mg. Cheapest verified path to FDA-approved ORAL semaglutide for weight loss. Verified
LillyDirect
Foundayo (brand, oral)
$199/moManufacturer directOral / pill2.5mg — step-up dose between starter and maintenance. Verified
Found
Foundayo (brand, oral)
$248/mo$149 med + $99 membershipOral / pill$149 med (0.8mg starter) + $99 CORE membership on 12-month plan. Escalates by dose. Verified
Shed
Foundayo (brand, oral)
$274/mo$149 med + $125 membershipOral / pill$149 med (starter) + $125 membership. Fulfilled via LillyDirect. Escalates $149->$199->$299 by dose tier. Verified
Shed
Wegovy (brand)
$274/mo$149 med + $125 membershipOral / pillWegovy pill $149-$299 by dose + $125 membership (required for brand). Verified
Found
Wegovy (brand)
$297/mo$198 med + $99 membershipOral / pill$198 Wegovy pill + $99 CORE membership on 12-month plan. Verified
Hims
Foundayo (brand, oral)
$298/mo$149 med + $149 membershipOral / pill$149 med (0.8mg starter) + $149 membership ($39 first month). Higher doses cost more. Verified
Hers
Foundayo (brand, oral)
$298/mo$149 med + $149 membershipOral / pill$149 med (starter) + $149 membership ($39 first month). Higher doses cost more. Verified
Hims
Wegovy (brand)
$298/mo$149 med + $149 membershipOral / pill$149 Wegovy pill + $149 membership ($39 first month). Same price at all doses. Verified
Hers
Wegovy (brand)
$298/mo$149 med + $149 membershipOral / pill$149 Wegovy pill + $149 membership ($39 first month). Verified
LillyDirect
Foundayo (brand, oral)
$299/moManufacturer directOral / pill5.5mg and 9mg — mid maintenance dose. Verified
LillyDirect
Zepbound (brand)
$299/moManufacturer directInjectable2.5mg starter, Self Pay Journey Program. 5mg $399; 7.5-15mg $449. Verified
PlushCare
Zepbound (brand)
$319/mo$299 med + $20 membershipInjectable$299 Zepbound 2.5mg vial + $19.99 membership. 5mg $399; 7.5mg+ $449. Cheapest membership in the category. Verified
WeightWatchers Clinic
Wegovy (brand)
$323/mo$249 med + $74 membershipInjectable$249 med (12-month supply PAID UPFRONT, $2,988) + $74/mo WW Med+ membership. Verified
Shed
Wegovy (brand)
$324/mo$199 med + $125 membershipInjectableWegovy PEN from $199 (higher doses more) + $125 membership. Prior $149 reflected the pill, not the pen. Verified
Found
Wegovy (brand)
$347/mo$248 med + $99 membershipInjectable$248 Wegovy pen + $99 CORE membership on 12-month plan. Verified
Ro
Foundayo (brand, oral)
$348/mo$199 med + $149 membershipOral / pill$199 med + $149 Ro Body membership. Ongoing $199-$299 by dose. First month medication $149. Verified
Hims
Wegovy (brand)
$348/mo$199 med + $149 membershipInjectable$199 Wegovy pen + $149 membership ($39 first month). Same price at all doses. Verified
Hers
Wegovy (brand)
$348/mo$199 med + $149 membershipInjectable$199 Wegovy pen + $149 membership ($39 first month). Verified
Ro
Wegovy (brand)
$348/mo$199 med + $149 membershipOral / pill$199 med + $149 Ro Body membership. Annual prepay saves $50/mo; $74 membership on the annual plan. Verified
Ro
Wegovy (brand)
$348/mo$199 med + $149 membershipInjectable$199-$399 med by dose + $149 Ro Body membership. Annual prepay saves $150/mo on medication. Verified
Hims
Ozempic (brand)
$348/mo$199 med + $149 membershipInjectable$199 med + $149 membership. FDA-approved for T2D; off-label for weight loss only when clinically appropriate. Verified
Hers
Ozempic (brand)
$348/mo$199 med + $149 membershipInjectable$199 med starter + $149 membership ($39 first month). FDA-approved for T2D. Verified
LillyDirect
Foundayo (brand, oral)
$349/moManufacturer directOral / pill14.5mg and 17.2mg standard rate. DROPS to $299 with a refill within 45 days of previous delivery — its own 45-day rule, parallel to Zepbound's. Verified
NovoCare Pharmacy
Wegovy (brand)
$349/moManufacturer directInjectableMonth 3 onward, all maintenance doses. Cut from $499 in November 2025. Verified
NovoCare Pharmacy
Ozempic (brand)
$349/moManufacturer directInjectable0.25-1mg ongoing; $499 for the 2mg dose. FDA-approved for T2D. Verified
PlushCare
Wegovy (brand)
$419/mo$399 med + $20 membershipInjectable$399 med + $19.99 membership (first month free). $129 initial visit billed separately. Verified
WeightWatchers Clinic
Wegovy (brand)
$423/mo$349 med + $74 membershipInjectable$349 med + $74 WW Med+ membership ($25 first month). 12-month commitment available at $249/mo. Verified
Found
Zepbound (brand)
$447/mo$348 med + $99 membershipInjectable$348 Zepbound KwikPen + $99 CORE membership on 12-month plan. Verified
Hims
Zepbound (brand)
$448/mo$299 med + $149 membershipInjectable$299 Zepbound KwikPen + $149 membership ($39 first month). Higher doses cost more. Verified
Hers
Zepbound (brand)
$448/mo$299 med + $149 membershipInjectable$299 Zepbound 2.5mg single-dose VIAL + $149 membership. Passes through Lilly's vial pricing: $299/$399/$449; refill within 45 days to hold the rate. NOTE: the pre-filled KwikPen is NOT in Lilly's vial-only self-pay programme, so a KwikPen price from Hers is UNCONFIRMED — verify at checkout. Verified
LillyDirect
Zepbound (brand)
$449/moManufacturer directInjectable7.5mg-15mg. MUST refill within 45 days of the previous delivery or the price rises. Verified
Shed
Zepbound (brand)
$474/mo$349 med + $125 membershipInjectable$349 med ($349-$499 by dose) + $125 membership (required for brand). Was $299. Verified
Ro
Zepbound (brand)
$548/mo$399 med + $149 membershipInjectable$399-$449 med by dose + $149 Ro Body membership. First month medication $299. Verified
PlushCare
Ozempic (brand)
$1020/mo$1,000 med + $20 membershipInjectableRETAIL-LEVEL (~$1,000 med + $20 membership). NovoCare's direct programme is $349-$499 for the same drug. Verified
PlushCare
Mounjaro (brand)
$1120/mo$1,100 med + $20 membershipInjectableRETAIL (~$1,100 med + $20 membership). Lilly runs NO Mounjaro self-pay programme. Zepbound is the same molecule at $299-$449. Verified
Found
Ozempic (brand)
$1199/mo$1,100 med + $99 membershipInjectableRETAIL-LEVEL ($1,100 med + $99 membership). NovoCare sells it direct for $349. Verified
Found
Mounjaro (brand)
$1199/mo$1,100 med + $99 membershipInjectableRETAIL ($1,100 med + $99 membership). Zepbound is the identical molecule at $299-$449 via LillyDirect. Verified
Eden
Zepbound (brand)
$1498/mo$1,399 med + $99 membershipInjectableRETAIL-LEVEL. $1,399 med + $99 membership. LillyDirect sells the identical drug for $299-$449. Verified
Eden
Wegovy (brand)
$1794/mo$1,695 med + $99 membershipInjectableRETAIL-LEVEL. $1,695 med + $99 membership. NovoCare sells the identical drug direct for $149-$349. Verified
Hers
Mounjaro (brand)
$2048/mo$1,899 med + $149 membershipInjectableRETAIL ($1,899 med + $149 membership). No manufacturer self-pay programme exists for Mounjaro. Verified

The brand floor — the comparison that reframes everything

The comparison the affiliate sites will not runSeven offerings in this database are brand-name drugs resold at close to retail, while the manufacturer sells the identical medicine direct for a fraction of the price. Eden lists brand Wegovy at $1,794/month total; NovoCare sells it for $149-$349. Eden lists brand Zepbound at $1,498; LillyDirect sells it for $299-$449. Hers lists Mounjaro at $2,048.

These are not scams — the prices are disclosed. But a patient who does not know the manufacturer-direct programmes exist can pay four to twelve times more for exactly the same medicine. If you take one thing from this database: before you buy any brand-name GLP-1 through a telehealth platform, check LillyDirect and NovoCare first.
Compounded tirzepatide vs the brand floor — total monthly cost, July 6, 2026
$0$108$215$323$431NexLife — Microdose$147BRAND Foundayo oral (FDA-approved)$149Found — Injectable$169Enhance.MD — Injectable$169NexLife — Standard injecti$186Shed — Injectable$199Oak Longevity — Injectable$199NexLife — Oral tablet (ODT$199Shed — Sublingual$229Shed — Injectable$245Mochi Health — Injectable$278Enhance.MD — Injectable$280Eden — Injectable$298Noom Med — Injectable$299BRAND Zepbound 2.5mg (FDA-approved)$299Henry Meds — Oral / pill$349TrimRx — Injectable$349MEDVi — Injectable$399bmiMD — Injectable$399

The two brand lines are the benchmark. Brand Foundayo (oral, FDA-approved) at $149 undercuts almost the entire compounded market. Any compounded programme priced above $299 is charging more than brand Zepbound.

Why Mounjaro is not a cash-pay option

Do not pay cash for MounjaroMounjaro and Zepbound are the same molecule — tirzepatide. The only difference is the approved indication: Mounjaro for type 2 diabetes, Zepbound for weight management.

Lilly runs a self-pay programme for Zepbound and none for Mounjaro. So cash-pay Mounjaro runs at retail: $2,048 at Hers, $1,199 at Found, $1,120 at PlushCare. Brand Zepbound through LillyDirect is $299-$449 for the identical drug.

If you are paying cash and you want tirzepatide, you want Zepbound. Mounjaro makes financial sense only when insurance covers it, which generally requires a type 2 diabetes diagnosis.

The insurance pathway

Check this before comparing any cash priceEleven of the eighty-nine offerings in this database are introductory rates — and they are the ones that get quoted. Noom advertises $79; the ongoing price is $199. MEDVi advertises $179; refills are $299. TrimRx's $179 becomes $299. Eden's $39 membership becomes $99. Oak's oral $245 is a four-week supply, which is $266 normalised to a month.

You pay the ongoing rate for eleven of your twelve months. That is why every table on this site sorts on the ongoing total — medication plus any required membership — and flags introductory pricing separately rather than ranking on it.
Insurance-coordinated pathways — cheapest of all, if you have coverage
PathwayCostWhat it doesStatus
Brand + commercial coverage + savings cardas low as $25/moZepbound or Wegovy when the plan covers it. Beats every cash path here.Verified
Medicare GLP-1 Bridge (Wegovy)$50/moEligible Part D members, 1 Jul 2026 - 31 Dec 2027. Prior auth required.Verified
PlushCare$19.99/mo membership + copayCheapest membership in the category. Prior-auth support. $129 initial visit.Verified
Found (insurance option)$99/mo (12-mo) to $199/mo + ~$30/visitFree insurance check built in.Verified
Mochi Health$79/mo membership + copayCoordinates insurance for brand medication.Verified

Why tirzepatide costs more than semaglutide

Eleven of the eighty-nine offerings in this database are introductory rates — and they are the ones that get quoted. Noom advertises $79; the ongoing price is $199. MEDVi advertises $179; refills are $299. TrimRx's $179 becomes $299. Eden's $39 membership becomes $99. Oak's oral $245 is a four-week supply, which is $266 normalised to a month.

You pay the ongoing rate for eleven of your twelve months. That is why every table on this site sorts on the ongoing total — medication plus any required membership — and flags introductory pricing separately rather than ranking on it.

The full-year cost analysisLooking for the definitive answer on tirzepatide price? Our flagship analysis ranks 14 tirzepatide pathways by 12-month total cost rather than advertised monthly rate — including brand Zepbound, the 45-day refill trap and the microdose question. Read: Cheapest tirzepatide online in 2026 →

How we selected and ranked

We considered: Oak Longevity, NexLife, Found, Mochi Health, TrimRx. Each was scored under methodology v1.0 across six weighted categories. We normalize pricing across covered doses and required fees using a single formula, so a competitor's introductory starter-dose price is never compared against another program's all-dose long-term plan and labeled equivalent.

Why we label prices instead of just listing themA caution about every compounded-price figure you will read anywhere, including on this page. Comparison sites in this category publish flatly contradictory numbers for the same providers — we have seen the same program listed at $179 on one site and $259 on another in the same month, and 'cheapest tirzepatide' claims ranging from $99 to $169 depending on who is writing. Advertised rates also frequently apply only to a first month, a starter dose, or a 12-month prepaid commitment.

We therefore label every provider price with its evidence status rather than presenting all figures as equally solid, and we treat any compounded price we have not captured ourselves as Reported, not Verified. Brand pricing on this page is verified directly against manufacturer sources, which is why we lead with it.

The programs, ranked

#1 — Oak Longevity · Cheapest semaglutide Verified

Starting price
$133/mo semaglutide; $199 tirzepatide
Highest-dose price
Flat across all dosages
Commitment
Multi-month plan for headline rate
Pharmacy
Not independently verified
Clinician
Care team + physician review

Oak advertises one flat price across all dosages with no membership and no subscription — semaglutide from $133/month and tirzepatide from $199 on the multi-month plan. That makes it the cheapest compounded semaglutide in our set.

Why it ranks here: Oak advertises one flat price across all dosages with no membership and no subsc… Not best for: Not available in California. Month-to-month pricing is materially higher ($167–$299).

Full Oak Longevity review →

#2 — NexLife · Best bundled value Verified

Starting price
$147/mo (microdose)
Highest-dose price
Flat — no dose-based increase
Commitment
12-month or month-to-month
Pharmacy
Network disclosed: Red Rock, Hallandale, Absolute, Empower, DIRx (licences not yet independently verified by us)
Clinician
Medical Director: Adam Kennah, MD (NPI 1144260043, provider-supplied)

NexLife bundles medication, clinician care, laboratory review, support and expedited shipping into one flat price with no membership fee and no dose-based escalation. Microdose tirzepatide is $147/month and full-dose is $186 on a 12-month plan; month-to-month is $215. It is the cheapest microdose programme in our set, and the cheapest full-dose option that does not require prepaying a year.

Why it ranks here: NexLife bundles medication, clinician care, laboratory review, support and exped… Not best for: Found is cheaper on full-dose tirzepatide at $169 — but that requires prepaying 12 months (~$2,028). Oak Longevity is cheaper on semaglutide at $133. NexLife offers no brand pathway and no insurance coordination.

Full NexLife review →

#3 — Found · Cheapest with coaching Verified

Starting price
$169/mo (12-month prepaid)
Highest-dose price
Flat across all compounded GLP-1s and all doses
Commitment
12-month prepay for the headline rate
Pharmacy
Not independently verified
Clinician
Clinician network + behavioural coaching

Found restructured in 2026: the compounded medication is now INCLUDED in the plan price, flat across semaglutide, tirzepatide and liraglutide and across all doses. $169/month on the 12-month prepaid plan makes it the cheapest full-dose compounded tirzepatide in our set. The old $249-medication-plus-$99-membership split is retired.

Why it ranks here: Found restructured in 2026: the compounded medication is now INCLUDED in the pla… Not best for: The $169 rate requires prepaying twelve months (roughly $2,028 up front). Month-to-month is $289. Found also resells brand Mounjaro and Ozempic at roughly $1,100–$1,199/month — near-retail, when the manufacturers sell them direct for far less.

Full Found review →

#4 — Mochi Health · Best clinical support Verified

Starting price
$178/mo total (sema)
Highest-dose price
Flat at all doses
Commitment
Monthly; commitment tiers reduce membership
Pharmacy
Not independently verified
Clinician
Unlimited physician + dietitian access

Split billing — $99 medication plus a $79 membership for semaglutide ($178 total), or $199 plus $79 for tirzepatide ($278 total). Flat at all doses. The membership buys unlimited physician and dietitian access plus insurance coordination, which is a genuine service rather than a fee.

Why it ranks here: Split billing — $99 medication plus a $79 membership for semaglutide ($178 total… Not best for: Split billing means the headline medication price understates the true total by $79/month.

Full Mochi Health review →

#5 — TrimRx Verified

Starting price
$199/mo (sema, ongoing)
Highest-dose price
Flat at all doses
Commitment
Prepay tiers available
Pharmacy
Not independently verified
Clinician
Pending research

All-inclusive flat pricing with no separate membership. Compounded semaglutide is $199/month ongoing and tirzepatide $349 ongoing. Prepay tiers reduce this: tirzepatide runs $283/month on a 12-month prepay.

Why it ranks here: All-inclusive flat pricing with no separate membership. Compounded semaglutide i… Not best for: The widely-quoted <b>$179 headline is a FIRST-MONTH rate</b> — the ongoing month-to-month price is $299 for semaglutide and $399 for tirzepatide. Earlier figures of $259 matched no current tier. Confirm your exact plan at checkout.

Full TrimRx review →

Medical and regulatory context

Compounding status — read this before you enrolCompounded drugs are not FDA-approved: the agency does not review them for safety, effectiveness or quality before they are marketed. Federal law also bars compounding drugs that are essentially a copy of a commercially available approved product — a bar that is lifted only while the drug is on the FDA shortage list. Both shortages are over. The FDA declared the tirzepatide shortage resolved on October 2, 2024 and the semaglutide shortage resolved on February 21, 2025, and enforcement discretion ended for all compounders between February 18 and May 22, 2025. On April 30, 2026 the FDA went further, proposing to exclude semaglutide, tirzepatide and liraglutide from the 503B bulks list on a finding of no clinical need. Routine compounding of these molecules is therefore no longer lawful on the basis that made the market — a fact most comparison sites still describe as "permanent legitimacy." It is not.
FDA compounding timeline for semaglutide and tirzepatide — every date sourced to an FDA order or court decision
DateWhat happenedWhy it matters
March 2022Semaglutide (Wegovy) added to the FDA drug shortage list.Shortage begins — the legal window for compounding opens.
August 2022Ozempic (semaglutide) added to the shortage list.
December 15, 2022Tirzepatide (Mounjaro, Zepbound) added to the shortage list.Compounded tirzepatide becomes lawful under the shortage exception.
October 2, 2024FDA declares the tirzepatide shortage resolved.The legal basis for compounding tirzepatide as an 'essentially a copy' drug begins to close.
December 19, 2024FDA reaffirms the tirzepatide resolution in a declaratory order.Sets a 60-day (503A) / 90-day (503B) transition.
February 18, 2025503A enforcement discretion for tirzepatide ENDS.State-licensed pharmacies must stop compounding tirzepatide copies.
February 21, 2025FDA removes semaglutide from the shortage list.
March 19, 2025503B enforcement discretion for tirzepatide ENDS.Outsourcing facilities must stop compounding tirzepatide copies.
April 22, 2025503A enforcement discretion for semaglutide ENDS.
April 24, 2025Court denies the Outsourcing Facilities Association's injunction (semaglutide).OFA v. FDA, N.D. Tex. — FDA's determination stands.
May 7, 2025Court upholds FDA on tirzepatide in OFA v. FDA.The shortage-exception route is closed for both molecules.
May 22, 2025503B enforcement discretion for semaglutide ENDS.All shortage-based compounding of both molecules is now outside enforcement discretion.
April 30, 2026FDA proposes excluding semaglutide, tirzepatide and liraglutide from the 503B bulks list.Finding: no clinical need for outsourcing facilities to compound them from bulk. Comment period closed June 29, 2026.

Ranking by price alone would be irresponsible in a category where pharmacy legitimacy, clinician oversight and legal standing vary widely. Our scoring weights clinical safety and pharmacy transparency above raw price for exactly this reason.

The finding most comparison sites will not printThe economic case for compounded GLP-1 has narrowed sharply, and almost no comparison site says so. In 2023 the choice was roughly $1,000+/month for brand versus $150–$300 for compounded — a gap wide enough to justify real regulatory risk. As of July 12, 2026, brand Zepbound is $299–$449 through LillyDirect, brand Wegovy is $349 (or $149 for the oral tablet) through NovoCare, and both drop to roughly $25 with commercial coverage. Meanwhile compounded programs advertise $99–$299.

For a patient at a maintenance dose, the difference between a compounded program and the FDA-approved brand can now be under $150/month — and in the case of the oral Wegovy tablet at $149, brand can be cheaper than much of the compounded market. What you buy with that difference is an FDA-approved product, quality-verified before marketing, in a fixed-dose device that removes the dosing-error risk, from a supply chain that cannot be shut down mid-course by an injunction. That is a materially different trade than the one the category was built on.
Brand vs compounded — monthly cost, verified July 12, 2026
$0$364$728$1093$1457Wegovy tablet (brand, oral)$149Compounded — cheapest advertised$99Zepbound 2.5mg (brand, LillyDirect)$299Wegovy standard (brand)$349Zepbound maintenance (brand, in window)$449Zepbound maintenance (brand, window missed)$699Zepbound retail pen (list)$1,086Wegovy retail (list)$1,349

Brand figures are verified against manufacturer pricing pages. The compounded figure is the lowest advertised rate we have seen and is unverified. Note where the brand oral tablet sits.

What a commitment actually costs you

Before you commit to a long planA committed plan lowers the monthly figure and raises the risk. Before you sign one, ask what happens if you stop early — because a meaningful number of people do. Roughly one in five patients discontinues a GLP-1 within the first few months, most often because of gastrointestinal side effects. Others stop because insurance unexpectedly approves a brand product, or because they reach a goal weight, or because their circumstances change.

Providers differ enormously in what happens then. Some refund the unused portion. Some convert you to the month-to-month rate and bill the difference for months already taken. Some refund nothing. This is the single question people most often forget to ask, and it is the one most likely to cost them money.

Dose escalation: the risk the headline price hides

The question that matters more than the headline priceAsk what you will pay at your target maintenance dose, not at the starting dose. This is the difference between a programme that quotes a flat rate at every dose and one that escalates: MEDVi's compounded tirzepatide reaches $499/month at 10-15mg against a $399 headline; Shed's injectables rise with dose; Oak escalates $50-$75 per step. Over a year, on a full titration, the gap between a flat-rate programme and an escalating one can exceed $3,000 — far more than any difference in the advertised starting price.
Does the price rise with your dose?
ProviderPrice at higher dosesRisk
NexLifeSame at every covered doseNone — flat rate
Mochi HealthSame at all dosesNone
Enhance.MDSame at all dosesNone
EdenSame at all doses (compounded)None on compounded
TrimRxFlat ongoing rateNone
Oak LongevityFlat across dosagesNone
ShedIncreases at higher dosesMaterial — model at maintenance
MEDVi$399 → $499 at 10-15mgMaterial — $1,200/yr swing
LillyDirect (brand)$299 → $449; $699 if you miss the 45-day refillMaterial — set a reminder

The insurance pathway

Do this before anything elseCheck your insurance before you compare any cash price. If your plan covers Zepbound or Wegovy, the manufacturer savings card can bring your cost to roughly $25/month — which beats every cash option on this site by an order of magnitude, for an FDA-approved product.

Coverage is most common through employer-sponsored commercial plans. Zepbound is excluded from Medicare Part D for weight loss and from most state Medicaid programmes. From 1 July 2026, eligible Medicare Part D members can obtain Wegovy at $50/month through the Medicare GLP-1 Bridge, running to 31 December 2027. Expect prior-authorisation paperwork: typically a BMI of 30+, or 27+ with a weight-related condition.

PlushCare ($19.99/month), Found and Mochi will handle that paperwork for you. If you have coverage, that is worth more than any cash discount.

Dose caps: the other thing a low price can hide

A capped dose is not a discountWatch for dose caps as well as dose escalation. Noom Med's $199 compounded semaglutide programme is capped at 0.6mg — the STEP trials that established semaglutide's efficacy used 2.4mg. A capped programme is not a cheaper version of the same treatment; it is a lower-dose treatment, and the expected effect is correspondingly smaller. Noom's full-titration programme is $279.

How to verify any of this yourself

You should not take our word for a price, and you do not have to. Every figure here can be checked in a few minutes.

  1. Go to the provider's own pricing page. Not a comparison site — the provider's. Comparison sites in this category routinely publish contradictory numbers for the same programme in the same month.
  2. Find the ongoing price, not the headline. Look for the words "first month", "intro", "starting at" or "new patients". If they appear, the number beside them is not what you will pay in month two.
  3. Add the membership. If the medication and the membership are billed separately, add them. That sum is your real monthly cost.
  4. Ask what the highest dose costs. By email or chat, so you have it in writing.
  5. Ask about early cancellation before you commit to a plan longer than a month.
  6. Check the manufacturer. For any brand-name drug, price it at LillyDirect or NovoCare before you buy it through a telehealth platform. Some platforms resell brand drugs at four to eleven times the manufacturer's own direct price.

If a provider will not answer questions 4 or 5 in writing, that is itself information.

Every fee that can be attached to a GLP-1 programme

An advertised price is a headline. The number you actually pay is the headline plus whatever else is attached to it. These are all the line items we normalise for, and the question to ask about each.

Full cost normalisation checklist
Line itemWhat to askHow often it bites
Advertised starting priceIs this a first-month or introductory rate?Very often — TrimRx, MEDVi, Noom, Eden all advertise intro rates
Ongoing priceWhat do I pay in month two?This is the number that matters
Membership feeIs it required, and is it billed separately?Very often — Eden, Mochi, Hims, Hers, Ro, PlushCare
Consultation feeIs the initial visit billed separately?Sometimes — PlushCare charges $129 initially
Laboratory feeAre baseline labs included or billed to me?Varies; often unstated until intake
ShippingIncluded? Expedited? Cold-chain?Usually included; confirm it
SuppliesAre syringes, needles and sharps disposal included?Usually included on all-inclusive plans
Dose-based increaseWhat do I pay at the highest dose you cover?Material — MEDVi goes $399 to $499; Shed and Oak escalate
Dose ceiling / capIs there a maximum dose on this plan?Material — Noom's $199 plan caps at 0.6mg
Upfront paymentHow much do I pay today to get the advertised rate?Found's $169 requires roughly $2,028 up front
Renewal priceDoes the price change when the plan renews?Frequently unstated — get it in writing
Cancellation termsIf I stop in month three of twelve, what happens to my money?The most-forgotten question in the category

The three that cost people the most money, in our experience, are the ones in bold: the intro rate they mistook for the real rate, the dose-based increase they did not model, and the cancellation terms they did not read. None of those are hidden. All of them are simply not asked about.

A worked example

Two programmes. One advertises $179. The other advertises $186. Which is cheaper?

The same twelve months, honestly costed
Programme A (advertised $179)Programme B (advertised $186)
Month 1$179 (intro rate)$186
Months 2-12 (ongoing rate)$299 × 11 = $3,289$186 × 11 = $2,046
Membership (if any)$0$0
Dose-based increaseNone statedNone — flat at every dose
Twelve-month total$3,468$2,232
Effective monthly$289$186

Programme A advertises a lower number and costs $1,236 more per year. This is not a hypothetical: the figures are TrimRx's advertised semaglutide rate against NexLife's standard tirzepatide plan. The advertised prices are seven dollars apart. The real prices are over twelve hundred dollars apart.

Why the ranking rule matters more than the rankingThis is the entire reason we sort every table on this site by ongoing total cost rather than by advertised price. It is not a clever methodology. It is just the one that does not produce a false ranking.

The bottom line, by situation

You have insurance that covers the brand drug
Stop comparing cash prices. Brand Zepbound or Wegovy with the manufacturer savings card can be $25/month.
You are on Medicare
The Medicare GLP-1 Bridge gives eligible Part D members Wegovy at $50/month from 1 July 2026.
Cash-pay, full dose, lowest total cost
NexLife at $186/month, all-inclusive — $113/month below the brand floor. The next-cheapest full-dose option is TrimRx at $259.
Cash-pay, microdose or maintenance
NexLife at $147 or Enhance.MD at $169 — both roughly 1mg/week, below every SURMOUNT dose.
You want clinical support and insurance help
Mochi Health at $278 total. The membership buys unlimited physician and dietitian access.
You want the FDA-approved drug at the lowest price
LillyDirect Zepbound at $299 (2.5mg). Set a refill reminder for day 30-35 once you reach 7.5mg.
You are paying $350-$400 for compounded tirzepatide
Re-price today. You are at or above brand Zepbound's starting price for a product the FDA has not reviewed.
NexLife
$147/mo microdose · $186/mo full dose · all-inclusive, no membership

Medication, licensed-clinician care, laboratory review, support and expedited shipping in one flat price, with no dose-based escalation. All 50 states. Medical Director: Adam Kennah, MD.

See NexLife plans →Read our full NexLife review
We may earn a commission from this link — see disclosure

Limitations of this analysis

Every page on this site should tell you where it stops being reliable. This one stops here.

Prices decay quickly. This is the fastest-moving data we publish. Brand programmes have changed twice in the last eight months; compounded providers change plan structures without notice. Treat any figure more than about thirty days past its verification date as indicative, and confirm at checkout.

Competitor pricing is reported, not captured by us. We hold dated captures for brand pricing and for NexLife. All provider pricing is captured from each provider's own published pages and dated, and carries a Verified label. Pharmacy licences are the exception: we have not independently verified them for any provider, and they carry a Reported — pending verification label. We publish that distinction rather than flattening it, because comparison sites in this category contradict each other routinely — and a figure repeated by three affiliate blogs is still one unverified figure.

We have not audited pharmacy licences. Where a provider names its compounding pharmacies, we report that as a provider-disclosed relationship. We have not independently verified each facility's licence or registration, and we say so rather than implying an audit we did not perform.

Advertised availability is not your availability. Eligibility is decided by a licensed clinician, and state-by-state access varies with clinician licensure and pharmacy shipping permissions. No page can promise you a price you will actually be offered.

We are commercially funded. The publisher and certain principals have financial relationships with some of the providers listed here, and we may earn a commission from provider links. That is disclosed in the footer of every page. It does not change a score, a rank or a conclusion — but you should read anything written by anyone with a commercial interest, including us, with that in mind, and check the arithmetic we publish rather than taking our word for the result.

Frequently asked questions

How did you rank these programs?

Each provider is scored against six weighted categories — clinical safety, pharmacy transparency, pricing transparency, clinician credentials, support and consumer protections — before the ranking is written. See our methodology.

Why is the cheapest program not always #1?

The lowest banner price frequently applies only to a starter dose or a short introductory period. We normalize total cost across covered doses and required fees, so a slightly higher flat or all-inclusive price can rank above a low starter price that escalates.

Are these compounded medications FDA-approved?

No. Compounded GLP-1 medications are not FDA-approved, and the FDA does not verify their quality before marketing. Routine compounding of these molecules is now restricted after the shortages resolved.

Sources

  1. Each provider's pricing, terms and pharmacy-disclosure pages, captured July 12, 2026.
  2. U.S. Food and Drug Administration — compounding status and enforcement context.
  3. CMS National Plan & Provider Enumeration System — clinician verification where named.
  4. Our scoring methodology, v1.0.

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